Bioactive Small Molecules
Medchemexpress LLC MYC degrader 1 (compound A80.2HCl) | 2946670-96-6 | 99.6% | 626.07 | 1 MG
MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader that demonstrates anti-tumor activity. It works by restoring pRB1 protein activity and re-establishing the sensitivity of MYC-overexpressing cancer cells to CDK4/6 inhibitors.
- Degrades MYC in various cell lines.
- Reduces the IC50 of Palbociclib in T24 and UMUC14 cells.
- Enhances the inhibition of cell cycle genes and colony formation by Palbociclib in drug-resistant cancer cell lines.
- Inhibits the growth of T24 and UMUC14 xenograft tumors in mice.
- Enhances the inhibitory effect of Palbociclib on tumor growth in T24 xenograft mice.
Selleck Chemical LLC Cefepime E7089-50MG
Cefepime (BMY-28142) is a broad-spectrum and cross the blood-brain barrier cephalosporin Cefepime shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria Cefepime induces neurotoxicity
Selleck Chemical LLC GSK2795039 S8974-10MM/1ML
GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6 57 for NOX2-mediated activation of HRP/Amplex Red GSK2795039 inhibits reactive oxygen species (ROS) production NADPH consumption and reduces apoptosis
Selleck Chemical LLC Didox E2939-25MG
Didox (3 4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid Didox inhibits proliferation of resistant breast cancer cells
Medchemexpress LLC HY-14959 10mg Medchemexpress, Ulipristal CAS:159811-51-5 Purity:>98%
Medchemexpress, HY-14959 10mg Ulipristal CAS:159811-51-5 Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Tarenflurbil | 51543-40-9 | MFCD00869714 | >98.0% | 244.26 g/mol | C15H13FO2 | 1 ML
Tarenflurbil is the R-enantiomer of flurbiprofen supplied for research use in neuroscience and Alzheimer's disease studies. It modulates amyloid processing and inhibits RXRα LBD binding, making it suitable for in vitro and analytical applications. Typical purity is greater than 98% and molecular weight is 244.26 g/mol.
- R-enantiomer of flurbiprofen
- Used in Alzheimer's disease and neuroscience research
- Molecular formula C15H13FO2; molecular weight 244.26 g/mol
- Purity >98%
- Soluble in DMSO (100 mg/mL) and ethanol (50 mg/mL)
- Store powder at -20°C; store solutions at -80°C
Medchemexpress LLC N-Boc-hexahydro-1H-azepine-4-one | 188975-88-4 | 99.27% | 213.27 | 10 G
N-Boc-hexahydro-1H-azepine-4-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not for sale to patients.
- Biochemical reagent
- Biological material or organic compound for life science related research
- For research use only
Selleck Chemical LLC Carbidopa 25mg 28860-95-9
Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ¿ 2 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Basimglurant E4619-25MG
Basimglurant(RG7090 CTEP Derivative) is a potent and selective negative allosteric modulator of mGlu5 with a Kd of 1 1 nM It inhibits the function of mGluR5 thereby regulating glutamatergic neurotransmission
Cayman Chemical DOTA-NOCacetate 5mg
A synthetic peptide; has been conjugated to radioligands for use in PET imaging of neuroendocrine tumors and for tissue distribution studies in vivo
Selleck Chemical LLC BIIB129 E4643-5MG
BIIB129 is a unique brain-penetrant covalent inhibitor of Bruton s tyrosine kinase (BTK) with high kinome selectivity It exhibits efficacy in targeting B-cell proliferation in the central nervous system (CNS) making it a promising immunomodulatory therapy for multiple sclerosis (MS)
AdipoGen BIX 01294 . trihydrochloride,Chemical. CAS: 13923999-03-9
BIX 01294 . trihydrochloride, AdipoGen Life Sciences. Chemical. CAS: 1392399-03-9 | 935693-62-2 (free base). Formula: C28H38N6O2 . 3HCl. MW: 490.6 . 109.4. Selective and cell permeable G9a histone-lysine methyltransferase (HMTase) inhibitor. Does not compete with cofactor S-adenosylmethionine. Pluripotent stem cell inducer.
Selleck Chemical LLC Brepocitinib S8804-1G
Brepocitinib (PF-06700841 PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM 17 nM 77 nM for Tyk2 Jak1 and Jak2 respectively It has appropriate in-family selectivity against JAK2 and JAK3
Selleck Chemical LLC ES9-17 E5911-25MG
ES9-17 is a potent selective and reversible inhibitor of Clathrin-mediated endocytosis (CME) It bind to the N-terminal domain (nTD) of the clathrin heavy chain (CHC) inhibiting the uptake of FM4-64 and of several CME cargos in Arabidopsis
Selleck Chemical LLC Ornidazole E6017-1G
Ornidazole (Levo-) (Levornidazole (S)-Ornidazole) the levo-isomer of ornidazole is a third-generation nitroimidazole derivative It exhibits antiprotozoal and antibacterial properties against anaerobic bacteria